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Abstract A water-soluble spin probe, disodium 4-(4,8-sulfonatooxy-2-naphthyl)thioureylene-2,2,6,6-tetramethyl-1-piperidinyloxyl (TEMPO-T) was newly synthesized and characterized comparing with several different TEMPO derivatives from the view point of a possibility of utilization in the liposomal studies. Of TEMPO derivatives studied, TEMPO-T was the best probe because of the high water solubility, the less lipophilicity, the less leakiness from liposome, and the reliable stability to both temperature and pH changes.
Sunamoto et al. (Wed,) studied this question.
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