What question did this study set out to answer?

To develop CytoMod, an unsupervised clustering and regression method that identifies functional modules of co-signaling cytokines and evaluates their associations with clinical phenotypes.

June 18, 2019SHILAP Revista de lepidopterologíaOpen Access

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls

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Authors

LCLiel Cohen-LaviStanford University AFAndrew Fiore-GartlandCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa ARAdrienne G. RandolphUniversity of Colorado Hospital

Discussion

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Implication

Cohort study reveals modular cytokine co-signaling networks associated with clinical phenotypes in influenza patients, indicating generalizable immune biosignatures across health and infection.

Key Points

To develop CytoMod, an unsupervised clustering and regression method that identifies functional modules of co-signaling cytokines and evaluates their associations with clinical phenotypes.
Developed CytoMod to cluster multiplexed cytokine profiles into functional co-signaling modules using unsupervised clustering and regression.
Applied the framework to cytokine profiles and clinical phenotype data from three independent cohorts of subjects naturally infected with influenza and one cohort of healthy controls.
Cytokine modules showed statistically significant associations with clinical phenotypes in two of three influenza cohorts, often yielding stronger associations than individual cytokines alone.
Identified conserved cytokine 'cores' that co-clustered across all three influenza cohorts and were also co-expressed in healthy controls, demonstrating generalizability across health and disease.

Cite This Study

Cohen-Lavi et al. (2019) studied this question.

synapsesocial.com/papers/69d97a6294760e72e6a3ca7f https://doi.org/10.3389/fimmu.2019.01338

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Implication

Cohort study reveals modular cytokine co-signaling networks associated with clinical phenotypes in influenza patients, indicating generalizable immune biosignatures across health and infection.

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls

Discussion

Member takes

Implication

Key Points

Cite This Study

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls

Discussion

Member takes

Implication

Key Points

Cite This Study

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