Why the study?
Does low-molecular-weight heparin improve the lipid profile in hemodialysis patients compared to conventional heparin?
Population
76 hemodialysis patients aged 15-61 years receiving hemodialysis for 48 (range 10-169) months.
Comparison
Low-molecular-weight heparin in doses of… vs Conventional heparin for 12 months.
Design
RCT, Randomly switched half of the patients back to conventional heparin.
Follow-up
24 months (12 months run-in + 12 months randomized phase)
Authors
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Supports long-term LMWH over conventional heparin in hemodialysis; extends RCT evidence for sustained lipid improvement.
Does low-molecular-weight heparin improve the lipid profile in hemodialysis patients compared to conventional heparin?
Long-term use of low-molecular-weight heparin instead of conventional heparin for anticoagulation during hemodialysis significantly improves the lipid profile.
Elisaf et al. (1997) studied this question.