Electrogram‐guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes

Fatima M. Ezzeddine; Suraj Kapa; Andrew Rosenbaum; Lori A. Blauwet; Abhishek Deshmukh; Omar F. AbouEzzeddine; Joseph J. Maleszewski; Samuel J. Asirvatham; John P. Bois; John A. Schirger; Panithaya Chareonthaitawee; Konstantinos C. Siontis

doi:10.1111/jce.15191

July 27, 2021Journal of Cardiovascular Electrophysiology

Electrogram‐guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes

View at Publisher

Ask AI

Bookmark

Share

Why the study?

Does electrogram-guided endomyocardial biopsy improve diagnostic yield in patients with suspected cardiac sarcoidosis?

Key Points

To assess the diagnostic yield and outcome implications of electrogram-guided endomyocardial biopsy in patients with suspected cardiac sarcoidosis.
Evaluated electrogram-guided endomyocardial biopsy (EGM-Bx) in patients undergoing diagnostic workup for suspected cardiac sarcoidosis.
Assessed preprocedural imaging findings to identify substrate abnormalities for biopsy site selection.
Abnormal electrogram-guided biopsy demonstrated high sensitivity for establishing a definite diagnosis of cardiac sarcoidosis.
Electrogram-guided biopsy showed low specificity when used alone to confirm disease presence.
Incorporating preprocedural imaging substrate abnormalities to select biopsy sites was identified as a strategy to improve diagnostic yield.

Structured PICO

Does electrogram-guided endomyocardial biopsy improve diagnostic yield in patients with suspected cardiac sarcoidosis?

P

Population

Patients with suspected cardiac sarcoidosis (CS)

I

Intervention

Electrogram-guided endomyocardial biopsy (EGM-Bx)

O

Outcome

Diagnostic yield for establishing a definite CS diagnosissurrogate

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Electrogram-guided endomyocardial biopsy offers high sensitivity but low specificity for diagnosing cardiac sarcoidosis, and preprocedural imaging may further improve diagnostic yield.

Abstract

In patients with suspected CS, abnormal EGM-Bx has high sensitivity and low specificity for establishing a definite CS diagnosis. Consideration of substrate abnormalities apparent on preprocedural imaging as an adjunct for selection of biopsy sites may further improve EGM-Bx yield.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ezzeddine et al. (2021) studied this question.

synapsesocial.com/papers/69d97dba1ad561c6736846bd https://doi.org/10.1111/jce.15191

View at Publisher

Ask AI

Bookmark

Share

Electrogram‐guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Electrogram‐guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading