Why the study?
Does antibiotic prophylaxis with second- or third-generation cephalosporins improve outcomes in patients undergoing cardiac surgery?
Does antibiotic prophylaxis with second- or third-generation cephalosporins improve outcomes in patients undergoing cardiac surgery?
Second- or third-generation cephalosporins are supported for cardiac surgery prophylaxis, with a possible advantage to extending prophylaxis up to 48 hours post-operatively.
Supports second- or third-generation cephalosporins with possible 48-hour extension for cardiac surgery prophylaxis; extends meta-analytic evidence for guideline refinement.
Evidence supports second- or third-generation cephalosporins for cardiac surgery prophylaxis and points at a possible advantage of prophylaxis prolongation up to 48 h post-operatively.
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Lador et al. (2011) studied this question.
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