Palladium‐ and Ruthenium‐Catalyzed Cycloisomerization of Enynamides and Enynhydrazides: A Rapid Approach to Diverse Azacyclic Frameworks

Cycloisomerizations are amongst the most atom-economical methods to access valuable organic ring systems from simple acyclicstarting materials. 1,n-Enynes have been particularly explored as cycloisomerization substrates,t hus giving rise to ab road spectrum of products depending on the choice of catalyst and substrate.I nc ontrast, reports of 1,n-enynamide cycloisomerization are limited to p-acid activation of the ynamide This is surprising given the importance of azacycles in organic and medicinal chemistry,t ow hich enynamide cycloisomerization could provide aunique and sustainable entry.