POAG TM cells have defective mitochondrial function, which causes them to be abnormally vulnerable to Ca(2+) stress. The dysfunction in calcium regulation by these cells may contribute to the failure of this tissue to control IOP. Pharmacologic inhibitors of IP3R, MPTP opening, and cyclophilin D could have clinical implications for primary open-angle glaucoma.
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He et al. (2008) studied this question.
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