Why the study?
Does elevated Lipoprotein(a) increase the risk of coronary artery calcification and its progression in asymptomatic patients?
Does elevated Lipoprotein(a) increase the risk of coronary artery calcification and its progression in asymptomatic patients?
Elevated Lipoprotein(a) is significantly associated with the presence, severity, and progression of coronary artery calcium in asymptomatic patients, reinforcing its role as a driver of subclinical atherosclerosis.
Lp(a) testing may refine subclinical atherosclerosis risk assessment in asymptomatic patients; extends meta-analytic support but requires RCTs to guide practice.
Asymptomatic patients with elevated Lp(a) had 31% higher chances of having any coronary calcification (CAC > 0) and 29% higher chances of having more advanced calcification (CAC > 100). It increased the chances of having progression of coronary calcification over time by 43%. For each 1 mg/dL of Lp(a) there was an increment of 1% chance of having coronary calcification.
No takes yet. Share an insight, caveat, or question.
Martignoni et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: