Effect of a low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertriglyceridemia

Figures

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  FIGURE 1. A, Serum triglyceride and, B, cholesterol concentrations in dogs with hypertriglyceridemia before and after diet change. Samples 1 and 2 were collected while dogs were on their original diets. Samples 3 and 4 were collected approximately 8 and 12 weeks, respectively, after the dogs were placed on the study diet. There was a significant decrease in serum triglyceride (P < .001) and cholesterol (P < .001) concentrations after the diet change. The dotted lines represent the upper limit of the reference interval. See also Tables 4 and 5

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  FIGURE 2. One dimensional SIR plot showing classification of dogs into groups based on lipoprotein density distribution before the diet change. The vertical line represents the line that separates the 2 groups based on lipoprotein density distribution. The LDA value provides a ranking value for each dog. The dogs represented by the dots that are at the bottom of the graph are the dogs of the control group. Their lipoprotein profiles plot them all to the right of the vertical line. The dogs represented by the dots at the top of the graph are the dogs of group 1 (with hypertriglyceridemia) before the diet change. They are all classified as a separate group from the control dogs with the exception of 1 dog that is classified as borderline normal. LDA, linear discriminant analysis; SIR, sliced inverse regression

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  FIGURE 3. One dimensional SIR plot showing classification of dogs into groups based on lipoprotein profile analysis after the diet change. The vertical line represents the line that separates the 2 groups based on their lipoprotein profile analysis. The LDA value provides a ranking value for each dog. The dogs represented by the dots that are at the bottom of the graph are the dogs of the control group. Their lipoprotein profiles plot them all to the right of the vertical line. The dogs represented by the dots at the top of the graph are the dogs of group 1 (with hypertriglyceridemia) after the diet change. Nine of the 16 dogs are now classified to the right of the vertical line together with the control dogs, suggesting that they are considered normal based on their lipoprotein profile analysis. The remaining 7 dogs are classified separately from the control dogs even after the diet change. Note that there is a clear separation between dogs of group 1 that responded to the diet change and those that did not. LDA, linear discriminant analysis

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  FIGURE 4. Lipoprotein density profiles from a representative dog in group 1. A, Lipoprotein profile of the dog before the diet change. B, Lipoprotein profile of the same dog 8 weeks after the diet change. This dog had normal serum triglyceride and cholesterol concentrations at that point. Note the dramatic decrease in TRL. A decrease in LDL1 and increases in HDL2b and HDL2a are also evident. HDL, high‐density lipoproteins; LDL, low‐density lipoproteins; TRL, triglyceride‐rich lipoproteins