Why the study?
Does tallying HTG risk alleles discriminate between individuals with hypertriglyceridemia and normolipidemia?
Does tallying HTG risk alleles discriminate between individuals with hypertriglyceridemia and normolipidemia?
Genetic profiling of risk alleles shows potential for discriminating hypertriglyceridemia from normolipidemia, which may guide future personalized treatment.
Compared to other complex traits, genetic variants account for a high proportion of HTG diagnoses. By tallying the number of HTG risk alleles, it is possible to discriminate between individuals with HTG and normolipidemia, particularly in those with extreme scores. Future directions include finding the missing genetic component and determining whether genetic profiling can help with diagnosis or personalized treatment advice.
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Johansen et al. (2011) studied this question.
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