April 26, 2011Current Opinion in Lipidology124 citations
View Full PaperGenetic bases of hypertriglyceridemic phenotypes
Structured PICO
Does tallying HTG risk alleles discriminate between individuals with hypertriglyceridemia and normolipidemia?
P
Population
Individuals with hypertriglyceridemia (HTG) and normolipidemia
I
Intervention
Genetic profiling / tallying HTG risk alleles
O
Outcome
Discrimination between HTG and normolipidemia
Genetic profiling of risk alleles shows potential for discriminating hypertriglyceridemia from normolipidemia, which may guide future personalized treatment.
Abstract
Compared to other complex traits, genetic variants account for a high proportion of HTG diagnoses. By tallying the number of HTG risk alleles, it is possible to discriminate between individuals with HTG and normolipidemia, particularly in those with extreme scores. Future directions include finding the missing genetic component and determining whether genetic profiling can help with diagnosis or personalized treatment advice.