Why the study?
Does 1 g i.v. acetazolamide alter ophthalmic artery blood flow and pulsatile ocular blood volume in patients with high-grade carotid occlusive disease compared to healthy controls?
Does 1 g i.v. acetazolamide alter ophthalmic artery blood flow and pulsatile ocular blood volume in patients with high-grade carotid occlusive disease compared to healthy controls?
Patients with high-grade carotid occlusive disease exhibit reduced baseline ocular hemodynamics which are further compromised following acetazolamide administration.
Answers are grounded in this paper and cite their sources.
Suggests caution with acetazolamide testing in carotid occlusive disease; leaves open effects on outcomes and need for prospective studies.
Ophthalmic artery blood flow pattern and the pulsatile ocular blood volume changes in patients with hemodynamically significant carotid occlusive disease are described. Using transorbital Doppler ultrasonography and dynamic tonometry 45 patients with high-grade internal carotid artery stenosis or occlusion and 15 healthy controls were examined. The measurements were performed under baseline conditions and 30 min after 1 gi.v. acetazolamide administration. The velocity in the ophthalmic artery was significantly lower in patients compared with controls. Pulsatile ocular blood volume was also lower in patients than in controls under baseline conditions, and a further reduction was found after acetazolamide, despite the significant decrease of intraocular pressure. A different reaction was observed in eyes with chronic ocular ischaemia.
No takes yet. Share an insight, caveat, or question.
Kerty et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: