Why the study?
Despite widespread interest in injectable hydrogels for post-MI treatment, few approaches exist to image them upon injection to identify location, volume, and delivery pattern for clinical translation.
Does encapsulating iohexol in hyaluronic acid hydrogels enable noninvasive monitoring of hydrogel location in the myocardium using SPECT/CT?
Population
Acute porcine model of MI
Comparison
Intramyocardial injection of iohexol-encapsulated hyaluronic acid hydrogel
Design
Preclinical animal imaging study
Follow-up
3-4 days
Authors
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Supports preclinical hydrogel tracking research; leaves open clinical translation.
Does encapsulating iohexol in hyaluronic acid hydrogels enable noninvasive monitoring of hydrogel location in the myocardium using SPECT/CT?
Encapsulating iohexol in injectable hyaluronic acid hydrogels enables short-term noninvasive monitoring of their location in the myocardium using SPECT/CT.
Uman et al. (2020) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: