Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

Jeffrey A. Klomp; David Petillo; Natalie M. Niemi; Karl Dykema; Jindong Chen; Ximing J. Yang; Annika Sääf; Peter Zickert; Markus Aly; Ulf S.R. Bergerheim; Magnus Nordenskjöld; Sophie Gad; Sophie Giraud; Yves Denoux; Laurent Yonneau; Arnaud Méjean; Viorel Vasiliu; Richard J. Kahnoski; Jeffrey P. MacKeigan; Bin Tean Teh; Kyle A. Furge

doi:10.1186/1755-8794-3-59

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Abstract

Our results support a genetic distinction between BHDS-associated tumors and other renal neoplasias. In addition, deregulation of the PGC-1α-TFAM signaling axis is most pronounced in renal tumors that harbor FLCN mutations and in tumors from other organs that have relatively low expression of FLCN. These results are consistent with the recently discovered interaction between FLCN and AMPK and support a model in which FLCN is a regulator of mitochondrial function.

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Klomp et al. (2010) studied this question.

synapsesocial.com/papers/69d99e95c4712b0965a3c0a8 https://doi.org/10.1186/1755-8794-3-59

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Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

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Abstract

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Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

Ask about this paper

Abstract

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Cite This Study

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