SERINE β-LACTAMASES AND PENICILLIN-BINDING PROTEINS

Jean‐Marie Ghuysen

doi:10.1146/annurev.mi.45.100191.000345

October 1, 1991Annual Review of MicrobiologyOpen Access

SERINE β-LACTAMASES AND PENICILLIN-BINDING PROTEINS

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Key Points

To review the structural, catalytic, and evolutionary relationships between bacterial serine beta-lactamases and penicillin-binding proteins.
Synthesized molecular, crystallographic, and biochemical evidence evaluating serine-active enzymes involved in bacterial cell wall assembly and antibiotic resistance.
Highlights how penicillin-binding proteins essential for cross-linking peptidoglycan share an active-site serine mechanism with class A, C, and D beta-lactamases.
Describes evolutionary divergence where bacterial enzymes adapted from wall-building transpeptidases into efficient hydrolytic defense systems against beta-lactam antibiotics.

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Implication

Review outlines the functional links between serine beta-lactamases and penicillin-binding proteins, highlighting key mechanisms of bacterial antibiotic resistance.

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Jean‐Marie Ghuysen (1991) studied this question.

synapsesocial.com/papers/69d99f71387cf70698684bac https://doi.org/10.1146/annurev.mi.45.100191.000345

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SERINE β-LACTAMASES AND PENICILLIN-BINDING PROTEINS

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

SERINE β-LACTAMASES AND PENICILLIN-BINDING PROTEINS

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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