Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challenging after 35 Years

In 1968 Epstein-Barr virus (EBV; now human herpesvirus 4) was found to be the major cause of infectious mononucleosis (IM), a usually self-limited clinical syndrome ([10][1]). Only about 5% of adults in Western societies remain EBV uninfected; thus, antibody prevalence rates reach 95% or higher