Why the study?
Does wide angle geometry at cerebral bifurcations induce aneurysmogenic positive wall shear stress gradients?
Does wide angle geometry at cerebral bifurcations induce aneurysmogenic positive wall shear stress gradients?
Wide bifurcation angles in cerebral vessels induce high positive wall shear stress gradients, suggesting a geometric and mechanotransductive mechanism for aneurysm development.
No immediate clinical implications for aneurysm screening; hypothesis-generating for bifurcation geometry in human aneurysm risk.
Apical shear forces and spatial gradients are highly dependent on bifurcation and inflow vessel geometry. The development of aneurysmogenic positive WSSG as a function of angular geometry provides a mechanotransductive link for the association of wide bifurcations and aneurysm development. These results suggest therapeutic strategies aimed at altering underlying unfavorable geometry and deciphering the molecular endothelial response to shear gradients in a bid to disrupt the associated aneurysmal degeneration.
No takes yet. Share an insight, caveat, or question.
Lauric et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: