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January 9, 2019Science Translational Medicine371 citationsOpen Access

Reduced Non-Rapid Eye Movement Sleep Linked to Tau Pathology in Early Alzheimer’s Disease

Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease

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Authors

BLBrendan P. LuceyAMAustin McCulloughELEric C. Landsness

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Overview

Randomized trial examines tau pathology correlations with non-rapid eye movement sleep in cognitively normal individuals, suggesting implications for early cognitive impairment detection.

Key Points

  • This study aims to explore the relationship between non-rapid eye movement sleep and tau pathology in early Alzheimer’s disease.
  • Participants enrolled in longitudinal aging studies were monitored for sleep using EEG devices.
  • Cognitive performance, brain imaging, and cerebrospinal fluid biomarkers were analyzed.
  • Statistical adjustments were made for age, sex, and other covariates.
  • A significant inverse relationship was found between NREM sleep slow wave activity and tau pathology, particularly at lower frequencies (1-2 Hz).
  • Cognitively normal participants exhibited changes in NREM SWA that could indicate tau pathology presence.
  • The findings suggest NREM SWA may serve as an early marker for cognitive impairment related to Alzheimer’s disease.
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Cite This Study

Lucey et al. (2019) studied this question.

synapsesocial.com/papers/69d9a5889a6164e50fa3d2dbhttps://doi.org/10.1126/scitranslmed.aau6550
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