The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspirocyclopropane-1,3′-indolin-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent