SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Heeyoung Chae; Robert Augustin; Eva Gatineau; Eric Mayoux; Mohammed Bensellam; Nancy Antoine; Firas Khattab; Bao-Khanh Lai; Davide Brusa; Birgit Stierstorfer; Holger Klein; Bilal Singh; Lucie Ruiz; Michael Pieper; Michael Mark; Pedro L. Herrera; Fiona M. Gribble; Frank Reimann; Anne Wojtusciszyn; Christophe Broca; Nano Rita; Lorenzo Piemonti; Patrick Gilon

doi:10.1016/j.molmet.2020.101071

Abstract

The data indicate that the SGLT2i-induced increase of the plasma glucagon/insulin ratio in vivo does not result from a direct action of the gliflozins on islet cells.

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Chae et al. (2020) studied this question.

synapsesocial.com/papers/69d9ae102a25b240b7a3d727 https://doi.org/10.1016/j.molmet.2020.101071

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SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Abstract

Discussion

Cite This Study

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Abstract

Discussion

Cite This Study

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