Why the study?
Does Ang-2 increase retinal vascular permeability in diabetic retinopathy models?
Does Ang-2 increase retinal vascular permeability in diabetic retinopathy models?
Ang-2 is upregulated in diabetic retinopathy models and alters VE-cadherin function, leading to increased vascular permeability.
Ang-2 may mediate early retinal leakage in diabetic models; leaves open therapeutic targeting pending human studies.
Ang-2 mRNA and protein increased in the retinal tissues after 8 weeks of diabetes and in high-glucose-treated cells. Intravitreal injection of Ang-2 in rats produced a significant increase in retinal vascular permeability. Ang-2 increased HREC monolayer permeability that was associated with a decrease in VE-cadherin and a change in monolayer morphology. High glucose and Ang-2 produced a significant increase in VE-cadherin phosphorylation. CONCLUSIONS; Ang-2 is upregulated in the retina in an animal model of diabetes, and hyperglycemia induces the expression of Ang-2 in isolated retinal endothelial cells. Increased Ang-2 alters VE-cadherin function, leading to increased vascular permeability. Thus, Ang-2 may play an important role in increased vasopermeability in diabetic retinopathy.
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Rangasamy et al. (2011) studied this question.
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