New-onset epilepsy is associated with cardiac autonomic dysfunction, particularly in vagal tone, independent of antiepileptic drug use.
Should not yet change practice in new epilepsy; hypothesis-generating for autonomic contributions to adverse outcomes.
Subtle but definite cardiac autonomic dysfunction, especially in vagal tone, was identified in drug-naïve, new-onset epilepsy patients. Seizures can cause long-term and often progressive cardiac autonomic dysfunction which may be independent of concomitant antiepileptic drugs.
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Mativo et al. (2010) studied this question.
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