Why the study?
In mammals, most cardiomyocytes become polyploid, but common assumptions about cardiomyocyte ploidy lack experimental demonstration and key issues remain unresolved.
Design
Review
Authors
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Technical challenges and unresolved mechanistic links in cardiomyocyte ploidy persist; leaves open its role in cardiac regeneration.
This review evaluates assumptions about cardiomyocyte ploidy and highlights key unresolved issues regarding its role in heart regeneration.
Gan et al. (2019) studied this question.
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