A new method using midbody positioning and distance between daughter nuclei enables unequivocal identification of cardiomyocyte cell division in mice, reducing false positive proliferation events in regeneration studies.
May reduce false positives in murine regeneration assays; leaves open translation to human cardiomyocyte studies.
The 2 criteria provide a new method for identifying cardiomyocyte division and should be considered in future studies investigating cardiomyocyte turnover and regeneration after injury, in particular in the postnatal heart to prevent the assignment of false positive proliferation events.
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Hesse et al. (2018) studied this question.
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