Slow cycling, label-retaining cells exist at the bulge of the hair follicle, with high proliferative potential and clonogenicity. The putative bulge stem cells can contribute to the epidermis, outer root sheath, inner root sheath, hair shaft and sebaceous gland. However, they still lack certain markers to distinguish bulge stem cells from their progeny, and much work needs to focus on the interrelations between bulge cells and interfollicular keratinocyte stem cells, the relations between bulge cells and dermal papilla mesenchyme cells, and the mechanism of hair growth.
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Ma et al. (2004) studied this question.
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