Why the study?
Does antithrombotic drug use increase the risk of subdural hematoma?
Does antithrombotic drug use increase the risk of subdural hematoma?
The use of antithrombotic drugs, particularly the combination of a VKA and an antiplatelet, is associated with an increased risk of subdural hematoma.
Antithrombotic use, especially VKA plus antiplatelet, was associated with higher subdural hematoma risk; this observational link leaves open causation and needs prospective confirmation.
In Denmark, antithrombotic drug use was associated with higher risk of subdural hematoma; and the highest odds of subdural hematoma was associated with combined use of a VKA and an antiplatelet drug. The increased incidence of subdural hematoma from 2000 to 2015 appears to be associated with the increased use of antithrombotic drugs, particularly use of a VKA among older patients.
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Gaist et al. (2017) studied this question.
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