Why the study?
Does acetylcholine provocation testing safely identify risk of future clinical events in patients with INOCA or MINOCA?
Does acetylcholine provocation testing safely identify risk of future clinical events in patients with INOCA or MINOCA?
Acetylcholine provocation testing is safe and provides prognostic value for predicting future clinical events in patients with INOCA and MINOCA.
May support risk stratification with ACh testing in INOCA/MINOCA; hypothesis-generating and requires randomized confirmation before practice change.
ACh provocation testing is associated with a low risk of mild and transient complications, with a similar prevalence in both INOCA and MINOCA patients. Importantly, ACh provocation testing can help to identify patients at higher risk of future clinical events, suggesting a net clinical benefit derived from its use in this clinical setting.
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Montone et al. (2022) studied this question.
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