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Design
Preclinical
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Hypothesis-generating for PVAT-targeted vascular therapies; leaves open translation to human disease.
PVAT exerts its anti-contractile effects through two distinct mechanisms: (1) by releasing a transferable relaxing factor which induces endothelium-dependent relaxation through NO release and subsequent K(Ca) channel activation, and (2) by an endothelium-independent mechanism involving H2O2 and subsequent activation of sGC.
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Gao et al. (2007) studied this question.
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