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May 15, 2000European Heart Journal524 citationsOpen Access

Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE Study

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PWPetr Widimský

Key Points

  • To assess the feasibility and safety of transferring patients with acute myocardial infarction for primary angioplasty compared to thrombolytic therapy.
  • Multicentre randomized trial comparing three approaches: transport to angioplasty, immediate thrombolysis, and a combined strategy.

Structured PICO

Does transport to primary angioplasty reduce the combined clinical end-point of death, reinfarction, or stroke at 30 days in patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory compared to immediate thrombolysis?

P
Population
Patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory
I
Intervention
Transport to a tertiary angioplasty centre for primary angioplasty
C
Comparator
Immediate standard thrombolytic therapy at the community hospital
O
Outcome
Combined clinical end-point of death/reinfarction/stroke at 30 dayscomposite

Transferring patients with acute myocardial infarction from community hospitals to tertiary centers for primary angioplasty is safe and significantly reduces the 30-day composite of death, reinfarction, or stroke compared to onsite thrombolysis.

Abstract

Transferring patients from community hospitals to a tertiary angioplasty centre in the acute phase of myocardial infarction is feasible and safe. This strategy is associated with a significant reduction in the incidence of reinfarction and the combined clinical end-point of death/reinfarction/stroke at 30 days when compared to standard thrombolytic therapy at the community hospital.

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Cite This Study

Petr Widimský (2000) studied this question.

synapsesocial.com/papers/69d9dacc0d540cafc5837c85https://doi.org/10.1053/euhj.1999.1993
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