Circulating low-density neutrophils as biomarkers of resistance to first-line anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer

N Castro; I Labiano; M Martínez-Aguillo; AE Huerta; I Morilla; L Teijeira; D Serrano; I Caseda; A Lecumberri; I Amat; M Zuazo; L Chocarro; E Blanco; D Escors; G Kochan; J Fernández Irigoyen; R Vera; A Calvo; M Alsina; H Arasanz

doi:10.1016/j.tranon.2026.102755

Key Points

This research investigates the role of circulating low-density neutrophils as biomarkers for resistance to anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer.
Analyzed baseline levels of circulating low-density neutrophils in patients with non-small cell lung cancer.
Evaluated their predictive capability regarding resistance to immunotherapy.
Examined the effects of combining immunotherapy with chemotherapy on resistance mechanisms.
High baseline levels of circulating low-density neutrophils predict resistance to anti-PD-1/PD-L1 therapy.
Combining chemotherapy may help to overcome this resistance.
Targeted strategies against low-density neutrophils could improve immunotherapy outcomes.

Implication

Analyzing biomarkers of resistance in non-small cell lung cancer, suggesting new treatment strategies.

Abstract

High baseline LDNs predict resistance to ICI monotherapy in NSCLC and combination with chemotherapy may overcome this resistance. Additional therapeutic strategies targeting LDNs could enhance immunotherapy efficacy.

Discussion

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Cite This Study

Castro et al. (2026) studied this question.

synapsesocial.com/papers/69d9e47378050d08c1b75007 https://doi.org/10.1016/j.tranon.2026.102755

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Circulating low-density neutrophils as biomarkers of resistance to first-line anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Circulating low-density neutrophils as biomarkers of resistance to first-line anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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