B-Cell Lymphoma 2 Mitochondria-Mediated Apoptotic Pathway in Cervical Carcinoma

Introduction: Cervical carcinoma is a leading cause of female malignant-depended morbidity and mortality worldwide.Although modern gynecological screening, including Papanicolaou (PAP) test and human papillomavirus (HPV) DNA/m RNA tests, provides an optimal management in female health, there is an increasing need for understanding the role of specific molecular pathways implicated in the disease.Among them, apoptosis plays a crucial role in the progression of the malignancy and also in the response rates to chemo-targeted therapeutic regimens.Objective: The purpose of the current molecular review was to explore the role of mitochondrial-based anti-apoptotic and apoptotic pathways in cervical carcinoma molecular substrate and their established and also potential chemo-targeted inhibitors.Material and method: A systematic review of the literature was carried out based on the international database PubMed including 50 significant papers in the examined scientific field.The following keywords were used: apoptosis, mitochondria, cervical, carcinoma, B-cell lymphoma.Results: B-cell lymphoma (BCL) proteins' expression in cervical carcinoma demonstrates differences among the corresponding patients.Especially, overactivation of BCL-2 seems to lead in an aggressive cervical carcinoma phenotype (advanced stage, poor prognosis) due to its strong anti-apoptotic action. BCL Proteins in CerviCaL CarCinoma