ObjectiveThis study aimed to assess the prognostic significance of the triglyceride-glucose index in predicting clinical outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy.MethodsThis study analyzed 811 patients with anterior circulation large-vessel occlusion who underwent endovascular thrombectomy for acute ischemic stroke. The triglyceride-glucose index was calculated as ln (fasting blood glucose (mg/dL) × fasting triglycerides (mg/dL)/2). A favorable outcome at 90 days was defined as a modified Rankin Scale score of 0-2.ResultsA higher triglyceride-glucose index was significantly associated with an unfavorable prognosis (odds ratio: 1.831, 95% confidence interval: 1.346 to 2.492), demonstrating a linear relationship. Incorporation of the triglyceride-glucose index into baseline models significantly improved risk classification and discrimination, as reflected by net reclassification improvement and integrated discrimination improvement (both p 0.05). This association remained significant across key subgroups, including older patients (odds ratio: 1.823, 95% confidence interval: 1.320 to 2.519), patients with successful reperfusion (odds ratio: 1.797, 95% confidence interval: 1.351 to 2.392), and those with high Alberta Stroke Program Early CT Score (odds ratio: 1.712, 95% confidence interval: 1.294 to 2.265).ConclusionThe triglyceride-glucose index is an independent predictor of functional outcome in patients with acute ischemic stroke undergoing endovascular thrombectomy, highlighting its potential for risk stratification.
Yang et al. (Wed,) studied this question.