Network meta-analysis shows antiangiogenic combinations improve outcomes in advanced NSCLC, indicating tailored treatment strategies.
This network meta-analysis demonstrates that antiangiogenic combinations improve outcomes in driver-negative advanced NSCLC. Endostar + chemotherapy offers the greatest OS benefit, atezolizumab-bevacizumab-chemotherapy improves ORR, and sintilimab-anlotinib provides superior PFS with lower toxicity. Treatment should be tailored based on clinical factors, with further validation in multiethnic trials.
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Li et al. (2026) studied this question.
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