A systematic literature review reviews treatment failure definitions and implications in females with uncomplicated urinary tract infections, suggesting the need for clearer metrics.
Treatment failure definitions have been variably defined in the literature. Symptom scores in clinical trials and the need for additional antibiotics or healthcare visits are meaningful outcomes that could underly treatment failure definitions in future studies. The optimal time for each outcome assessment needs further evaluation.
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Luck et al. (2026) studied this question.
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