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April 11, 2026Chemical Science3 citationsOpen Access

PANDA: AND Logic-Gated RNA Sensing Enabled by Photo-Activated RCA-Argonaute Cascade

XKXinxin KeHFHeming FanJQJingwen Qu

Key Points

  • The research aims to enhance nucleic acid detection methods using a novel approach involving RCA and Argonaute proteins.
  • Developed a one-pot PANDA system for RNA sensing.
  • Utilized photo-activated rolling circle amplification (RCA).
  • Incorporated Argonaute proteins for improved detection capability.
  • Achieved stable and multiplexed detection of nucleic acids.
  • Demonstrated affordability and efficiency of the PANDA system.
  • Enabled effective RNA sensing in various conditions.

Abstract

Achieving stable, multiplexed, and affordable nucleic acid detection in a true one-pot format remains a long-standing challenge for molecular diagnostics. Here, we report PANDA, a photo-activated rolling circle amplification (RCA)-Argonaute...

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Cite This Study

Ke et al. (2026) studied this question.

synapsesocial.com/papers/69d9e57078050d08c1b75af9https://doi.org/10.1039/d6sc00827e
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