Development of Biocompatible Polymer Based Synthetic Wound Dressing

Biocompatible hydrogel wound dressings have garnered interest for their capacity to promote the regeneration of dermal and epidermal tissues. This study generated a biocompatible hydrogel wound dressing with Pluronic F127 and chitosan functionalized with Ala-Leu dipeptide nanotubes. The biocompatible structure was studied using FTIR, SEM-EDX, and TG-DTA analyses. The analysis results validated the synthesized structure by instrumental approaches. The synthesized material's biological effects were assessed via antibacterial activity against E. coli, P. aeruginosa, S. aureus, and S. pyogenes, cytotoxicity tests with HS2, and wound healing evaluations using HS2. No notable antibacterial, cytotoxic, or wound-healing properties of the synthesized substance were observed. Hydrogels synthesized from chitosan functionalized with Ala-Leu dipeptide nanotubes can be enhanced with antimicrobial agents and wound healing promoters for use as therapeutic carrier wound dressings or in injectable gel form.