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Cross-sectional study analyzes IPD trends in Canada, highlighting vaccine coverage gaps in adults, suggesting need for new strategies.
This cross-sectional study of IPD isolates in Canada found that despite initial IPD reductions following PCVs, IPD in Canada increased, driven by emerging nonvaccine types and persistence of some vaccine serotypes. Indirect protection was limited, particularly among older adults, highlighting the need for direct adult vaccination strategies. These findings suggest that while PCV15, PCV20, and PCV21 may improve serotype coverage, continued development of broader-spectrum vaccines is essential to further reduce IPD burden.
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Ramos et al. (2026) studied this question.
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