NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression

This is the authors' abstract. We don't add key points for this paper.

NFATc1 stimulates NAFLD progression through chronic ER stress sensing and subsequent activation of terminal UPR signalling in hepatocytes. Interfering with ER stress-responses, for example, by TUDCA, protects fatty livers from progression towards manifest NASH.