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April 11, 2026CNS Neuroscience & Therapeutics2 citationsOpen Access

Astrocyte‐Derived Exosomal miR ‐211‐5p Alleviates Blood–Brain Barrier Injury in a Rat Model of Traumatic Brain Injury

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YCYan ChenXYXuan YinEZErwei Zhang

Key Points

  • The study aims to investigate the neuroprotective effects of astrocyte-derived exosomal miR-211-5p on blood-brain barrier integrity in traumatic brain injury (TBI).
  • Utilized a rat model of traumatic brain injury
  • Administered exosomal miR-211-5p from astrocytes
  • Analyzed effects on glial activation and neuroinflammation
  • Assessed blood-brain barrier integrity
  • Exosomal miR-211-5p significantly reduced glial activation
  • Decreased levels of neuroinflammation observed
  • Preserved blood-brain barrier integrity post-injury

Abstract

Astrocyte-derived exosomal miR-211-5p confers neuroprotection in TBI by modulating glial activation, reducing neuroinflammation, and preserving BBB integrity. These findings underscore the therapeutic potential of miR-211-5p-loaded exosomes as a cell-free, targeted intervention for brain trauma.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69d9e63478050d08c1b76824https://doi.org/10.1002/cns.70858
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