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A case reveals adenoid cystic carcinoma identified through PSMA PET/CT imaging in a man with prostate cancer, suggesting broader application for this imaging technique.
PSMA PET, widely used in prostate cancer, targets a transmembrane glycoprotein overexpressed in tumor cells, and PSMA expression is also seen in some nonprostatic tumors and normal tissues. In this case, a 66-year-old man with biopsy-proven prostate adenocarcinoma and PSA 16 ng/mL underwent 68Ga-PSMA PET/CT for staging. Focal uptake consistent with primary prostate malignancy was detected in the mid-prostate, predominantly left lateral. In addition, a polypoid intraluminal tracheal lesion demonstrated intense PSMA expression. Histopathology confirmed adenoid cystic carcinoma, emphasizing the modality's value beyond prostate cancer.
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Sabuncu et al. (2026) studied this question.
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