Fxr/Cyp2c70-DKO mice show increased hepatocytic injury, suggesting implications for cholestatic liver disease.
Fxr/Cyp2c70-DKO mice exhibit more severe hepatocytic injury than Fxr-KO mice, mirroring the clinical phenotype of FXR deficiency. These data highlight the importance of studying the aetiology of cholestatic liver diseases in the context of a human-like BA composition.
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Vries et al. (2026) studied this question.
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