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April 11, 2026Nature and Science of Sleep0 citationsOpen Access

Association of Blood Count Inflammatory Markers with Sleep Problems

Association of Complete Blood Count-Derived Inflammatory Markers with Trouble Sleeping: Evidence from Population Data and Experimental Sleep Deprivation

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Authors

CDChujun DuanYZYuan ZhangPFPeng Fang

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Overview

Population data shows associations between inflammatory markers and sleep issues, suggesting health evaluations may benefit.

Key Points

  • To investigate how blood-derived inflammatory markers relate to trouble sleeping.
  • Analyzed data from 39,156 NHANES participants (2011-2018) using logistic regression.
  • Employed restricted cubic splines to explore nonlinear relationships.
  • Conducted a human study assessing effects of 36 hours of sleep deprivation.
  • Measured inflammatory markers and cytokines before and after recovery sleep.
  • Participants with sleep issues reported shorter sleep duration and higher inflammatory markers.
  • Monocyte-to-lymphocyte ratio significantly correlated with sleep insufficiency (p < 0.001).
  • Systemic inflammation response index was an independent predictor of sleep troubles (OR = 1.07).
  • IL-6 levels remained elevated despite recovery after sleep deprivation.
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Cite This Study

Duan et al. (2026) studied this question.

synapsesocial.com/papers/69d9e64e78050d08c1b76953https://doi.org/10.2147/nss.s587638
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