Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway

Meng Chen; Ruiyuan Zhang; Ying Huang; Ying Huang; Yuxin Pan; Jie Yang; Yinghong Huang; Yinghong Huang

doi:10.1080/09513590.2026.2655498

April 9, 2026Gynecological EndocrinologyOpen Access

Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway

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Key Points

The research aims to evaluate the effects of the Bushen Huatan formula on reproductive and metabolic disorders in non-obese polycystic ovary syndrome rats.
Utilized non-obese polycystic ovary syndrome rats for experimentation.
Administered Bushen Huatan formula to the experimental group.
Analyzed the role of adipose tissue-derived exosomal miR-27a-3p in the signaling pathway affecting PPARG.
Bushen Huatan formula reduced the inhibitory effects of miR-27a-3p.
Improved reproductive and endocrine function was observed in the treated rats.

Implication

Demonstrates BSHT alleviates reproductive endocrine disorders in PCOS rats, indicating potential therapeutic benefits.

Abstract

This study demonstrates that the BSHT prescription may alleviate reproductive endocrine disorders in PCOS rats by mitigating the inhibitory effects of fat-derived exosomal miR-27a-3p on PPARG.

Discussion

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69d9e66378050d08c1b76c9d https://doi.org/10.1080/09513590.2026.2655498

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Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Bushen Huatan formula improves reproductive and endocrine metabolic disorders in non-obese polycystic ovary syndrome rats via adipose tissue-derived exosomal miR-27a-3p/PPARG signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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