Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection

祁琛(Chen QI)

doi:10.26036/cnp0009264

January 1, 2026Open Access

Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection

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Key Points

The research aims to discover and engineer a new BvCas12a nuclease for enhancing genome editing and nucleic acid detection in mammalian cells.
Utilized target amplicon sequencing to analyze on/off target sites
Conducted experiments using HEK293T cells for testing the nuclease
Engineered the BvCas12a nuclease for optimized performance
Demonstrated effective genome editing capabilities in HEK293T cells
Achieved precise nucleic acid detection using the engineered BvCas12a nuclease
Validated both on-target and off-target effects through sequencing analysis

Implication

Discovery engineers a new BvCas12a nuclease for genome editing and nucleic acid detection, suggesting potential applications in genetic research.

Abstract

Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection. Target amplicon sequencing of on/off target sites from HEK293T cells.

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Cite This Study

祁琛(Chen QI) (2026) studied this question.

synapsesocial.com/papers/69d9e67a78050d08c1b76d9b https://doi.org/10.26036/cnp0009264

View Full Paper

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Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection

Key Points

Implication

Abstract

Discussion

Cite This Study

Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection

Key Points

Implication

Abstract

Discussion

Cite This Study

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