Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

Sumit Gupta; Lu Liu; Joshua Demb; Jiyue Qin; Ashley Earles; Mark Lamm; X. T. Huang; Shailja C. Shah; Neetu Chawla; Yi Le; Tamra Burns Loeb; Jason A. Dominitz; D. S. Robertson; Nancy L. Schoenborn; Audrey H. Calderwood; Theodore R. Levin; Benjamin Seligman; Folasade P. May

doi:10.1001/jama.2026.3414

Key Points

To evaluate the risk of colorectal cancer (CRC) and mortality among older adults with adenoma found during previous colonoscopy.
Examined adults aged 75 years and older
Compared CRC outcomes in those with and without adenoma from previous colonoscopy
Assessed cumulative risks of CRC and non-CRC mortality
Older adults with adenoma had a higher likelihood of developing subsequent CRC and CRC-related deaths
Cumulative risks of CRC were low
Non-CRC death risks substantially outweighed CRC death risks

Implication

Observational study compares CRC risk in older adults with and without adenoma, suggesting focus on other health issues.

Abstract

Adults 75 years of age or older with adenoma at prior colonoscopy were more likely to experience subsequent CRC and CRC death compared with those without adenoma, but cumulative risks were low and were far exceeded by competing risks for non-CRC death. Older adults may consider deprioritizing surveillance colonoscopy relative to other health concerns.

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Cite This Study

Gupta et al. (2026) studied this question.

synapsesocial.com/papers/69d9e67a78050d08c1b76d9d https://doi.org/10.1001/jama.2026.3414

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Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

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