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April 11, 2026Journal of Gastroenterology and Hepatology2 citations

Ten vs. 14 Days of Vonoprazan‐Based Therapy for Helicobacter pylori : Systematic Review and Meta‐Analysis of Randomized Trials

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TATareq AlsalehCFCelise Nardes FerreiraHAHina Akram

Key Points

  • This research aims to compare the efficacy and side effects of ten-day vs. fourteen-day vonoprazan-based therapy for Helicobacter pylori eradication.
  • Conducted a systematic review and meta-analysis of randomized trials
  • Focused on trials conducted in China
  • Compared outcomes of ten-day and fourteen-day therapy schedules
  • Fourteen-day therapy shows a modest benefit in eradication rates, especially with dual therapy.
  • Ten-day therapy results in fewer side effects, including nausea, vomiting, and taste disturbances.
  • Data derived solely from trials in China, limiting generalizability.

Abstract

Fourteen-day therapy provides a modest eradication benefit, most evident in dual therapy. Ten-day therapy is associated with fewer nausea/vomiting and taste disturbances. Findings are based entirely on trials from China and may not generalize elsewhere.

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Cite This Study

Alsaleh et al. (2026) studied this question.

synapsesocial.com/papers/69d9e67a78050d08c1b76e61https://doi.org/10.1111/jgh.70367
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