Comparison of HPMCAS Chemical Grades (L, M, and H) for Amorphous Solid Dispersion by Hot-Melt Extrusion. II: Polymer-Drug-Surfactant Miscibility and Drug Release with Itraconazole as a Model Drug

Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is commonly used to develop amorphous solid dispersions (ASDs), but its use is mostly limited to spray-dried preparations. Although hot-melt extrusion (HME) is a simpler, continuous method for preparing ASDs, it is rarely used with HPMCAS.