Beyond the Colon: Clostridioides d ifficile Enteritis Presenting Following a Nissen Fundoplication

Clostridioides difficile enteritis (CDE) is a rare condition usually seen in patients with recent abdominal surgery and/or antibiotics. A 49-year-old male patient presented following a Nissen fundoplication surgery with watery diarrhea, abdominal pain, tenderness, tachycardia, and hypotension. Stool polymerase chain reaction for C. difficile was positive, enzyme immunoassay negative. Abdominal CT was suggestive of enteritis. He was treated with a course of oral vancomycin. This study highlights that CDE can occur following other surgeries apart from ileostomy/colectomy and should be on the differential for high-risk patients (hospitalization, proton pump inhibitor (PPI) use, and antibiotic exposure).