Key result
Higher aspirin doses in ACS increase bleeding without improving efficacy compared to 75-100 mg daily.
Why the study?
The relationship between aspirin dose, bleeding risk, and efficacy when used alone or with clopidogrel in ACS patients was unclear.
Does the dose of aspirin affect efficacy and bleeding risk when used alone or with clopidogrel in patients with acute coronary syndromes?
Does the dose of aspirin affect efficacy and bleeding risk when used alone or with clopidogrel in patients with acute coronary syndromes?
The optimal daily dose of aspirin in patients with ACS is between 75 and 100 mg, as higher doses increase bleeding risk without improving efficacy.
Supports 75-100 mg aspirin daily in ACS; challenges higher-dose strategies in practice and trials.
In patients with ACS, adding clopidogrel to aspirin is beneficial regardless of aspirin dose. Bleeding risks increase with increasing aspirin dose, with or without clopidogrel, without any increase in efficacy. Our findings suggest that the optimal daily dose of aspirin may be between 75 and 100 mg, with or without clopidogrel.
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Peters et al. (2003) studied this question. Higher aspirin doses in acute coronary syndrome patients increase bleeding risk without improving efficacy, suggesting an optimal daily dose of 75 to 100 mg regardless of clopidogrel use.
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