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There is evidence linking insulin re-sistance with low-grade chronic in-flammation (1). Proinflammatory cytokines, such as tumor necrosis fac-tor- and interleukin (IL)-6,might impair insulin action (2,3). Little is known about associations between insulin action and anti-inflammatory cytokines. IL-10 is a cytokine with potent anti-inflammatory properties (4). Recent studies provided evidence that IL-10 might exert some beneficial metabolic effects (5–7). So far, no data are available regarding an associ-ation between circulating IL-10 and insu-lin action in humans. The aim of the present study was to examine the rela-tionship between plasma IL-10 concen-tration andwhole-body insulin sensitivity in apparently healthy humans.
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Strączkowski et al. (2005) studied this question.
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