Does Trem2/Tyrobp signaling protect against aortic dissection and rupture in mice?
Trem2/Tyrobp signaling protects against aortic dissection and rupture in mice, suggesting a potential novel therapeutic target for human aortic dissection.
Our findings suggest a novel role for the Trem2/Tyrobp axis in AD development in mice. Enhancement of Trem2/Tyrobp signaling may represent a promising strategy for the prevention and treatment of AD. Future studies to clarify the role of Trem2/Tyrobp in human AD are warranted.
Zhang et al. (Thu,) studied this question.